(Peer-Reviewed) Protective effects on acute hypoxic-ischemic brain damage in mfat-1 transgenic mice by alleviating neuroinflammation
Geng Xue 耿雪 ¹, Wang Meng 王蒙 ¹, Leng Yunjun 冷允俊 ¹, Li Lin 李琳 ¹, Yang Haiyuan 杨海元 ¹ ², Dai Yifan 戴一凡 ¹ ², Wang Ying 王盈 ¹ ²
¹ Jiangsu Key Laboratory of Xenotransplantation, Nanjing Medical University, Nanjing, Jiangsu 211166, China
中国 江苏 南京 南京医科大学 江苏省异种移植重点实验室
² Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University. Nanjing, Jiangsu 211166, China
中国 江苏 南京 南京医科大学 心血管病转化医学协同创新中心 心血管病分子干预重点实验室
Abstract
Acute hypoxic-ischemic brain damage (HIBD) mainly occurs in adults as a result of perioperative cardiac arrest and asphyxia. The benefits of n-3 polyunsaturated fatty acids (n-3 PUFAs) in maintaining brain growth and development are well documented. However, possible protective targets and underlying mechanisms of mfat-1 mice on HIBD require further investigation.
The mfat-1 transgenic mice exhibited protective effects on HIBD, as indicated by reduced infarct range and improved neurobehavioral defects. RNA-seq analysis showed that multiple pathways and targets were involved in this process, with the anti-inflammatory pathway as the most significant. This study has shown for the first time that mfat-1 has protective effects on HIBD in mice.
Activation of a G protein-coupled receptor 120 (GPR120)-related anti-inflammatory pathway may be associated with perioperative and postoperative complications, thus innovating clinical intervention strategy may potentially benefit patients with HIBD.
Unlocking home-based nocturnal health management: A fiber-optic approach for early detection of cardiorespiratory rhythm disorders
Hanyu Jin, Hao Li, Zhuolin Chen, Liangye Li, Zurui Wang, Kai Zhou, Weijian Hang, Zhipeng Chen, Junfeng Chen, Kai Shen, Jianfeng Wen, Chen Chen, Cunzheng Fan, Zhijun Yan, Feng Wang, Qizhen Sun
Opto-Electronic Advances
2026-07-10
A flexible wireless system for prospective photodynamic therapy applications
Rolan Mansour, Bhavani Yalagala, Vikas Vikas, Nikolas Bruce, Fawziye Tarhini, Georgios N. Arvanitakis, Mohammed Mughal, Jamie Blanche, Ahmad Taha, Jonathan Copper, Muhammad Imran, Karin Williams, Karin Oien, Mahmoud Wagih, Hadi Heidari, Robert Hadfield, David Flynn
Opto-Electronic Advances
2026-07-10
Parallel bright-field and multi-order edge imaging via wide field-of-view trichannel metalens
Xiaotong Li, Yeseul Kim, Youngsun Jeon, Junhwa Seong, Jaekyung Kim, Peng Tang, Shiqi Hu, Harit Keawmuang, Beomha Yang, Dongmin Jeon, Le Dai, Weiyan Li, Xiaodong Cai, Jinhui Shi, Yong-Sang Ryu, Trevon Badloe, Junsuk Rho
Opto-Electronic Advances
2026-07-10
