(Peer-Reviewed) Protective effects on acute hypoxic-ischemic brain damage in mfat-1 transgenic mice by alleviating neuroinflammation
Geng Xue 耿雪 ¹, Wang Meng 王蒙 ¹, Leng Yunjun 冷允俊 ¹, Li Lin 李琳 ¹, Yang Haiyuan 杨海元 ¹ ², Dai Yifan 戴一凡 ¹ ², Wang Ying 王盈 ¹ ²
¹ Jiangsu Key Laboratory of Xenotransplantation, Nanjing Medical University, Nanjing, Jiangsu 211166, China
中国 江苏 南京 南京医科大学 江苏省异种移植重点实验室
² Key Laboratory of Targeted Intervention of Cardiovascular Disease, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, Nanjing Medical University. Nanjing, Jiangsu 211166, China
中国 江苏 南京 南京医科大学 心血管病转化医学协同创新中心 心血管病分子干预重点实验室
Abstract
Acute hypoxic-ischemic brain damage (HIBD) mainly occurs in adults as a result of perioperative cardiac arrest and asphyxia. The benefits of n-3 polyunsaturated fatty acids (n-3 PUFAs) in maintaining brain growth and development are well documented. However, possible protective targets and underlying mechanisms of mfat-1 mice on HIBD require further investigation.
The mfat-1 transgenic mice exhibited protective effects on HIBD, as indicated by reduced infarct range and improved neurobehavioral defects. RNA-seq analysis showed that multiple pathways and targets were involved in this process, with the anti-inflammatory pathway as the most significant. This study has shown for the first time that mfat-1 has protective effects on HIBD in mice.
Activation of a G protein-coupled receptor 120 (GPR120)-related anti-inflammatory pathway may be associated with perioperative and postoperative complications, thus innovating clinical intervention strategy may potentially benefit patients with HIBD.
Triplet exciton harvesting via TADF in hafnium chlorides array scintillator screen enables ultrahigh-resolution X-ray imaging
Jun'an Lai, Yi Ye, Xu Liu, Sijun Cao, Shiji Zhou, Wenxia Zhang, Kang An, Peng He, Tingming Jiang, Xiaosheng Tang, Rui Zhou, Dong Zhang
Opto-Electronic Advances
2026-06-08
Vacancy oscillating mode in amorphous binary oxide film by terahertz time domain spectroscopy
Huan Liu, Haiyun Huang, Heng Yu, Zhi Gong, Fei Yu, Zheng Zhang, Zhiyong Tan, Juncheng Cao, Haiyun Liu, Kan-Hao Xue, Xiangshui Miao, Yan Liu, Yue Hao, Genquan Han, Qihua Xiong
Opto-Electronic Advances
2026-06-08
Emerging optical techniques for sorting and detection of chiral particles
Yuzhi Shi, Chengfeng Li, Xiaolei Lin, Wenwen Xue, Chengxing Lai, Tao He, Qinghua Song, Zhanshan Wang, Yulan Wang, Din Ping Tsai, Xinbin Cheng, Haidong Zou
Opto-Electronic Advances
2026-06-08
Phonon-assisted absorption photoconductive switch
Zhao Wang, Lixin Zhang, Lu Cheng, Danwen Zhang, Yu Lu, Naiji Zhang, Xin Zhang, Duanyang Chen, Zhan Sui, Hongji Qi, Wei Zheng
Opto-Electronic Science
2026-05-25
Photonic spiking reinforcement learning for intelligent routing
Shuiying Xiang, Yonghang Chen, Ling Zheng, Zhicong Tu, Xintao Zeng, Mengting Yu, Shuai Wang, Yahui Zhang, Xingxing Guo, Weitao Pan, Yue Hao
Opto-Electronic Science
2026-05-25
