Year
Month
(Peer-Reviewed) Experimental investigation of early assessment of corpora cavernosa fibrosis with two-dimensional shear wave elastography
Li Yu ¹, Wan-Ting Rao ², Jing-Dong Tang 汤敬东 ³, Jin-Fang Xing 邢晋放 ² ³
¹ Department of Special Inspection, Shanghai Shibei Hospital of Jing'an District, Shanghai 200435, China
中国 上海 上海市静安区市北医院特检科
² Department of Medical Ultrasound, Fudan University Pudong Medical Center, Shanghai 201399, China
中国 上海 复旦大学附属浦东医院超声医学科
³ Shanghai Key Laboratory of Vascular Lesions Regulation and Remodeling, Fudan University Pudong Medical Center, Shanghai 201399, China
中国 上海 复旦大学附属浦东医院 上海市血管病变调控与重塑重点实验室
Asian Journal of Andrology, 2021-09-03
Abstract

This study explored the usefulness of two-dimensional shear wave elastography (2D-SWE) in the early assessment of corpora cavernosa fibrosis (CCF). New Zealand male rabbits were randomly assigned to an experimental group or a control group.

Recombinant human transforming growth factor beta 1 (TGF-β1) was injected into the dorsal penis tissue of rabbits in the experimental group. Conventional ultrasound and 2D-SWE examinations were performed before and 20 days after injection. Penile histological analysis was performed by hematoxylin–eosin staining, sirius red staining, and immunohistochemistry. Measurement of 2D-SWE examination results was performed using shear wave elastography quantitative measurement (SWQ). Histological analysis outcomes were the proportion of smooth muscle cells (SMCs), collagen fibers (CFs), collagen type I (Col I), and collagen type III (Col III), as well as the SMCs/CFs ratio, measured by sirius red staining.

Other histological analysis outcomes were the positive area proportion (PAP) of TGF-β1 (PAPT), fibronectin (PAPF), and Col III (PAPC), measured by immunohistochemistry. After recombinant human TGF-β1 injection, SWQ was higher in the experimental group than that in the control group (P < 0.001); however, there were no differences in conventional ultrasound results. There were significant differences in histological outcomes between the two groups (all P < 0.05). These results indicated that 2D-SWE was superior for identifying early histological changes in CCF.
Experimental investigation of early assessment of corpora cavernosa fibrosis with two-dimensional shear wave elastography_1
Experimental investigation of early assessment of corpora cavernosa fibrosis with two-dimensional shear wave elastography_2
Experimental investigation of early assessment of corpora cavernosa fibrosis with two-dimensional shear wave elastography_3
Experimental investigation of early assessment of corpora cavernosa fibrosis with two-dimensional shear wave elastography_4
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