(Peer-Reviewed) Scattered seeding of CAR T cells in solid tumors augments anticancer efficacy
Hongjun Li 李洪军 ¹ ² ³ ⁴ ⁵, Zejun Wang 王则君 ³ ⁴ ⁵, Edikan Archibong ⁶ ⁷, Qing Wu ¹, Guojun Chen 陈国军 ³ ⁴ ⁵, Quanyin Hu ⁷, Tianyuan Ci 慈天元 ³ ⁴ ⁵, Zhaowei Chen 陈兆委 ¹ ³ ⁴ ⁵, Jinqiang Wang 王金强 ¹ ³ ⁴ ⁵, Di Wen 温迪 ³ ⁴ ⁵, Hongwei Du 杜红伟 ⁶ ⁷, Jie Jiang ⁸, Jie Sun 孙洁 ⁸, Xingcai Zhang 张兴才 ⁹, Gianpietro Dotti ⁶ ⁷, Zhen Gu 顾臻 ¹ ² ³ ⁴ ⁵
¹ College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
中国 杭州 浙江大学药学院
² Liangzhu Laboratory, Zhejiang University Medical Center, Sir Run Run Shaw Hospital,
Hangzhou 310058, China
中国 杭州 邵逸夫医院 浙江大学医学中心良渚实验室
³ Department of Bioengineering, University of California, Los Angeles, CA 90095 USA
⁴ Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA 90095 USA
⁵ California NanoSystems Institute, University of California, Los Angeles, CA 90095 USA
⁶ Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, NC 27695, USA
⁷ Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA
⁸ Department of Cell Biology and Bone Marrow Transplantation Center of the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China
中国 杭州 浙江大学医学院 附属第一医院 骨髓移植中心
⁹ John A. Paulson School of Engineering and Applied Sciences, Harvard University, Cambridge, MA 02138, USA
National Science Review, 2021-09-21

Chimeric antigen receptor T cell (CAR T) therapy reached a milestone in the treatment of relapsed and refractory B-cell malignancies. However, beneficial effects of CAR T cells have not been obtained in solid tumors yet. Herein, we implemented a porous microneedle patch that accommodates CAR T cells and allows in situ penetration-mediated seeding of CAR T cells when implanted in the tumor bed or in post-surgical resection cavity.

CAR T cells loaded in the pores of the microneedle tips were readily escorted to the tumor in an evenly scattered manner without losing their activity. Such microneedle-mediated local delivery enhanced infiltration and immunostimulation of CAR T cells as compared to direct intratumoral injection. This tailorable patch offers a transformative platform for scattered seeding of living cells for treating a variety of tumors.
Scattered seeding of CAR T cells in solid tumors augments anticancer efficacy_1
Scattered seeding of CAR T cells in solid tumors augments anticancer efficacy_2
Scattered seeding of CAR T cells in solid tumors augments anticancer efficacy_3
  • Power grid fault diagnosis based on a deep pyramid convolutional neural network
  • Xu Zhang 张旭, Huiting Zhang, Dongying Zhang, Yixian Wang, Ruiting Ding, Yuchuan Zheng, Yongxu Zhang
  • CSEE Journal of Power and Energy Systems
  • 2022-05-06
  • China's factor reallocation effect considering energy
  • Guangqing Xu, Xiaoyu Chen
  • Chinese Journal of Population, Resources and Environment
  • 2022-05-02
  • Cannabidiol prevents depressive-like behaviors through the modulation of neural stem cell differentiation
  • Ming Hou, Suji Wang, Dandan Yu, Xinyi Lu, Xiansen Zhao, Zhangpeng Chen, Chao Yan
  • Frontiers of Medicine
  • 2022-04-26
  • Cultivation of gut microorganisms of the marine ascidian Halocynthia roretzi reveals their potential roles in the environmental adaptation of their host
  • Yang Yang, Yuting Zhu, Haiming Liu, Jiankai Wei, Haiyan Yu, Bo Dong
  • Marine Life Science & Technology
  • 2022-04-26
  • Data network traffic analysis and optimization strategy of real-time power grid dynamic monitoring system for wide-frequency measurements
  • Jinsong Li, Hao Liu, Wenzhuo Li, Tianshu Bi, Mingyang Zhao
  • Global Energy Interconnection
  • 2022-04-25
  • Field distribution of the Z₂ topological edge state revealed by cathodoluminescence nanoscopy
  • Xiao He, Donglin Liu, Hongfei Wang, Liheng Zheng, Bo Xu, Biye Xie, Meiling Jiang, Zhixin Liu, Jin Zhang, Minghui Lu, Zheyu Fang
  • Opto-Electronic Advances
  • 2022-04-25
  • Advances in femtosecond laser direct writing of fiber Bragg gratings in multicore fibers: technology, sensor and laser applications
  • Alexey Wolf, Alexander Dostovalov, Kirill Bronnikov, Mikhail Skvortsov, Stefan Wabnitz, Sergey Babin
  • Opto-Electronic Advances
  • 2022-04-25
  • Graphene-empowered dynamic metasurfaces and metadevices
  • Chao Zeng, Hua Lu, Dong Mao, Yueqing Du, He Hua, Wei Zhao, Jianlin Zhao
  • Opto-Electronic Advances
  • 2022-04-25
  • Charge carrier dynamics in different crystal phases of CH₃NH₃PbI₃ perovskite
  • Efthymis Serpetzoglou, Ioannis Konidakis, George Kourmoulakis, Ioanna Demeridou, Konstantinos Chatzimanolis, Christos Zervos, George Kioseoglou, Emmanuel Kymakis, Emmanuel Stratakis
  • Opto-Electronic Science
  • 2022-04-21
  • Applications of optically and electrically driven nanoscale bowtie antennas
  • Zhongjun Jiang, Yingjian Liu, Liang Wang
  • Opto-Electronic Science
  • 2022-04-20
  • Validation of the bodily expressive action stimulus test among Chinese adults and children
  • Yunmei Yang, Wenwen Hou, Jing Li
  • PsyCh Journal
  • 2022-04-17

  • Lowering the Carbon Emissions Peak and Accelerating the Transition Towards Net Zero Carbon                                Intrinsically inert hyperbranched interlayer for enhanced stability of organic solar cells
    Copyright © PubCard