(Peer-Reviewed) Hepatorenal syndrome in acute-on-chronic liver failure with acute kidney injury: more questions requiring discussion
Songtao Liu 刘松涛 ¹ ², Qinghua Meng 孟庆华 ², Yuan Xu 许媛 ³, Jianxin Zhou 周建新 ¹
¹ Department of Critical Care Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, P. R. China
中国 北京 首都医科大学附属北京天坛医院重症医学科
² Department of Severe Liver Disease, Beijing You’an Hospital, Capital Medical University, Beijing, P. R. China
中国 北京 首都医科大学附属北京佑安医院重症肝病科
³ Department of Critical Care Medicine, Beijing Tsinghua Chang Gung Hospital, Beijing, P. R. China
中国 北京 北京清华长庚医院重症医学科
Gastroenterology Report, 2021-09-25
Abstract
In cirrhosis with ascites, hepatorenal syndrome (HRS) is a specific prerenal dysfunction unresponsive to fluid volume expansion. Acute-on-chronic liver failure (ACLF) comprises a group of clinical syndromes with multiple organ failure and early high mortality. There are differences in the characterization of ACLF between the Eastern and Western medical communities. Patients with ACLF and acute kidney injury (AKI) have more structural injuries, contributing to confusion in diagnosing HRS-AKI.
In this review, we discuss progress in the pathogenesis, diagnosis, and management of HRS-AKI, especially in patients with ACLF. Controversy regarding HRS-AKI in ACLF and acute liver failure, hepatic carcinoma, shock, sepsis, and chronic kidney disease is also discussed. Research on the treatment of HRS-AKI with ACLF needs to be more actively pursued to improve disease prognosis.
Massively parallel and programmable photonic differential equation solver
Jiahao Wang, Wen Chen, Zhou Zhou, Dongyu Hu, Zile Li, Peng Chen, Yan-qing Lu, Shuang Zhang, Cheng-Wei Qiu, Shaohua Yu, Guoxing Zheng
Opto-Electronic Advances
2026-05-15
Femtosecond laser rapid customization of high-performance anti-reflection windows
Yulong Ding, Xiang Jiang, Cong Wang, Xianshi Jia, Linpeng Liu, Weina Han, Zheng Gao, Shiyu Wang, Nai Lin, Dejin Yan, Ji'an Duan
Opto-Electronic Science
2026-04-23
Ppt-level volatile organic compounds detection via microsecond-pulse-enhanced mid-infrared photoacoustic
Senyu Wang, Liang Zhao, Hongyu Luo, Xiangyu Zhao, Jianfeng Li, Wei Wang, Hao Lei, Mingrui Jiang, Jinlong Wan, Binxing Zhao, Bincheng Li, Yong Liu
Opto-Electronic Science
2026-04-23
AI-assisted metaphotonics
Minsung Kang, Seokju Choi, Kaixi Fu, Xiaoyuan Liu, Zhun Wei, Lei Jin, Hao Wang, Olivier J. F. Martin, Joel K. W. Yang, Sunae So, Trevon Badloe
Opto-Electronic Advances
2026-04-17
Terahertz imaging technology: progress and applications
Yuyuan Tian, Xiaoyin Chen, Zhuocheng Zhang, Qianze Yan, Yiming Liu, Chengliang Deng, Min Wan, Jiang Li, Xiaoqiuyan Zhang, Lu Rong, Elizaveta Tsiplakova, Nikolay Petrov, Xinke Wang, Liguo Zhu, Min Hu, Yan Zhang
Opto-Electronic Technology
2026-03-30
