Year
Month
(Peer-Reviewed) Inactivated SARS-CoV-2 vaccine does not influence the profile of prothrombotic antibody nor increase the risk of thrombosis in a prospective Chinese cohort
Tingting Liu 刘婷婷 ¹, Jing Dai ², Zhitao Yang 杨志涛 ³, Xiaoqi Yu ⁴, Yanping Xu ⁵ ⁶ ⁷, Xinming Shi ², Dong Wei ⁴, Zihan Tang ¹, Guanqun Xu 徐冠群 ², Wenxin Xu ⁴, Yu Liu ², Ce Shi ², Qi Ni 倪琪 ², Chengde Yang 杨程德 ¹, Xinxin Zhang 张欣欣 ⁴, Xuefeng Wang 王学锋 ², Erzhen Chen 陈尔真 ³, Jieming Qu 瞿介明 ⁵ ⁶ ⁷
¹ Department of Rheumatology and Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China 上海交通大学医学院附属瑞金医院 风湿免疫科
² Department of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China 上海交通大学医学院附属瑞金医院 检验科
³ Department of Emergency, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China 上海交通大学医学院附属瑞金医院 急诊科
⁴ Department of Infectious Diseases, Research Laboratory of Clinical Virology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China 上海交通大学医学院附属瑞金医院 感染科 临床病毒学研究室
⁵ Department of Pulmonary and Critical Care Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China 上海交通大学医学院附属瑞金医院 呼吸与危重症医学科
⁶ Institute of Respiratory Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China 上海交通大学医学院 呼吸疾病研究所
⁷ Shanghai Key Laboratory of Emergency Prevention, Diagnosis and Treatment of Respiratory Infectious Diseases, Shanghai 200025, China
Science Bulletin, 2021-07-27
Abstract

The presence of antiphospholipid antibodies was shown to be associated with thrombosis in coronavirus disease 2019 (COVID-19) patients. Recently, according to reports from several studies, the vaccine-induced immune thrombotic thrombocytopenia is mediated by anti-platelet factor 4 (PF4)-polyanion complex in adenovirus-vectored COVID-19 vaccine recipients. It is impendent to explore whether inactivated COVID-19 vaccine widely used in China influences prothrombotic autoantibody production and induces thrombosis.

In this prospective study, we recruited 406 healthcare workers who received two doses, 21 days apart, of inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine (BBIBP-CorV, Sinopharm). Paired blood samples taken before vaccination and four weeks after the second vaccination were used in detecting prothrombotic autoantibodies, including anticardiolipin (aCL), anti-β2 glycoprotein I (aβ2GP1), anti-phosphatidylserine/prothrombin (aPS/PT), and anti-PF4-heparin.

The seroconversion rate of SARS-CoV-2 specific antibodies was 95.81% (389/406) four weeks after vaccination. None of the subjects had spontaneous thrombosis or thrombocytopenia over a minimum follow-up period of eight weeks. There was no significant difference in the presence of all ten autoantibodies between samples collected before and after vaccination: for aCL, IgG (7 vs. 8, P = 0.76), IgM (41 vs. 44, P = 0.73), IgA (4 vs. 4, P = 1.00); anti-β2GP1, IgG (7 vs. 6, P = 0.78), IgM (6 vs. 5, P = 0.76), IgA (3 vs. 5, P = 0.72); aPS/PT IgG (0 vs. 0, P = 1.00), IgM (6 vs. 5, P = 0.76); aPF4-heparin (2 vs. 7, P = 0.18), and antinuclear antibody (ANA) (18 vs. 21, P = 0.62).

Notably, seven cases presented with anti-PF4-heparin antibodies (range: 1.18–1.79 U/mL) after vaccination, and none of them exhibited any sign of thrombotic disorder. In conclusion, inactivated SARS-CoV-2 vaccine does not influence the profile of antiphospholipid antibody and anti-PF4-heparin antibody nor increase the risk of thrombosis.
Inactivated SARS-CoV-2 vaccine does not influence the profile of prothrombotic antibody nor increase the risk of thrombosis in a prospective Chinese cohort_1
Inactivated SARS-CoV-2 vaccine does not influence the profile of prothrombotic antibody nor increase the risk of thrombosis in a prospective Chinese cohort_2
Inactivated SARS-CoV-2 vaccine does not influence the profile of prothrombotic antibody nor increase the risk of thrombosis in a prospective Chinese cohort_3
Inactivated SARS-CoV-2 vaccine does not influence the profile of prothrombotic antibody nor increase the risk of thrombosis in a prospective Chinese cohort_4
  • Influence of N-doping on dielectric properties of carbon-coated copper nanocomposites in the microwave and terahertz ranges
  • Feirong Huang, Shuting Fan, Yuqi Tian, Xinghao Qu, Xiyang Li, Maofan Qin, Javid Muhammad, Xuefeng Zhang, Zhidong Zhang, Xinglong Dong
  • Journal of Materiomics
  • 2022-11-06
  • Towards integrated mode-division demultiplexing spectrometer by deep learning
  • Ze-huan Zheng, Sheng-ke Zhu, Ying Chen, Huanyang Chen, Jin-hui Chen
  • Opto-Electronic Science
  • 2022-11-01
  • Discovery of novel aspartate derivatives as highly potent and selective FXIa inhibitors
  • Ling Zhang, Wei Chen, Ningning Yao, Shuzeng Hou, Zhiwei Meng, Yi Kong, Chenzhong Liao, Zhouling Xie
  • Journal of Chinese Pharmaceutical Sciences
  • 2022-10-31
  • Switching of K-Q intervalley trions fine structure and their dynamics in n-doped monolayer WS₂
  • Jiajie Pei, Xue Liu, Andrés Granados del Águila, Di Bao, Sheng Liu, Mohamed-Raouf AMARA, Weijie Zhao, Feng Zhang, Congya You, Yongzhe Zhang, Kenji Watanabe, Takashi Taniguchi, Han Zhang, Qihua Xiong
  • Opto-Electronic Advances
  • 2022-10-28
  • Low-loss chip-scale programmable silicon photonic processor
  • Yiwei Xie, Shihan Hong, Hao Yan, Changping Zhang, Long Zhang, Leimeng Zhuang, Daoxin Dai
  • Opto-Electronic Advances
  • 2022-10-28
  • Large-scale and high-quality III-nitride membranes through microcavity-assisted crack propagation by engineering tensile-stressed Ni layers
  • Jung-Hong Min, Kwangjae Lee, Tae-Hoon Chung, Jung-Wook Min, Kuang-Hui L1, Chun Hong Kang, Hoe-Min Kwak, Tae-Hyeon Kim, Youyou Yuan, Kyoung-Kook Kim, Dong-Seon Lee, Tien Khee Ng, Boon S. Ooi
  • Opto-Electronic Science
  • 2022-10-28
  • Metasurface-based nanoprinting: principle, design and advances
  • Rao Fu, Kuixian Chen, Zile Li, Shaohua Yu, Guoxing Zheng
  • Opto-Electronic Science
  • 2022-10-28
  • Table-top optical parametric chirped pulse amplifiers: past and present
  • Audrius Dubietis, Aidas Matijošius
  • Opto-Electronic Advances
  • 2022-09-30
  • ZnO nanowires based degradable high-performance photodetectors for eco-friendly green electronics
  • Bhavani Prasad Yalagala, Abhishek Singh Dahiya, Ravinder Dahiya
  • Opto-Electronic Advances
  • 2022-09-30
  • Crosstalk-free achromatic full Stokes imaging polarimetry metasurface enabled by polarization-dependent phase optimization
  • Yaxin Zhang, Mingbo Pu, Jinjin Jin1, Xinjian Lu, Yinghui Guo, Jixiang Cai, Fei Zhang, Yingli Ha, Qiong He, Mingfeng Xu, Xiong Li, Xiaoliang Ma, Xiangang Luo
  • Opto-Electronic Advances
  • 2022-09-30
  • All-optical logic gate computing for high-speed parallel information processing
  • Shuming Jiao, Junwei Liu, Liwen Zhang, Feihong Yu, Guomeng Zuo, Jingming Zhang, Fang Zhao, Weihao Lin, Liyang Shao
  • Opto-Electronic Science
  • 2022-09-07
  • 100 Hertz frame-rate switching three-dimensional orbital angular momentum multiplexing holography via cross convolution
  • Weijia Meng, Yilin Hua, Ke Cheng, Baoli Li, Tingting Liu, Qinyu Chen, Haitao Luan, Min Gu, Xinyuan Fang
  • Opto-Electronic Science
  • 2022-09-07



  • The COVID-19 Pandemic, Regional Cooperation Economic Partnership (RCEP) and the Rise of Investment Facilitation                                Non-spreading bessel spatiotemporal optical vortices
    About
    |
    Contact
    |
    Copyright © PubCard