(Peer-Reviewed) Tip-enhanced Raman scattering of glucose molecules
Zhonglin Xie 谢仲林 ¹, Chao Meng 孟超 ¹, Donghua Yue 岳东桦 ¹, Lei Xu 徐雷 ³, Ting Mei 梅霆 ¹, Wending Zhang 张文定 ¹ ²
¹ Key Laboratory of Light Field Manipulation and Information Acquisition, Ministry of Industry and Information Technology, School of Physical Science and Technology, Northwestern Polytechnical University, Xi'an 710129, China
中国 西安 西北工业大学物理科学与技术学院 光场调控与信息感知工业和信息化部重点实验室
² Research & Development Institute of Northwestern Polytechnical University in Shenzhen, Shenzhen 518063, China
中国 深圳 西北工业大学深圳研究院
³ Advanced Optics & Photonics Laboratory, Department of Engineering, School of Science & Technology, Nottingham Trent University, Nottingham NG11 8NS, United Kingdom
Opto-Electronic Science
, 2025-05-22
Abstract
Glucose molecules are of great significance being one of the most important molecules in metabolic chain. However, due to the small Raman scattering cross-section and weak/non-adsorption on bare metals, accurately obtaining their "fingerprint information" remains a huge obstacle. Herein, we developed a tip-enhanced Raman scattering (TERS) technique to address this challenge.
Adopting an optical fiber radial vector mode internally illuminates the plasmonic fiber tip to effectively suppress the background noise while generating a strong electric-field enhanced tip hotspot. Furthermore, the tip hotspot approaching the glucose molecules was manipulated via the shear-force feedback to provide more freedom for selecting substrates.
Consequently, our TERS technique achieves the visualization of all Raman modes of glucose molecules within spectral window of 400–3200 cm−1, which is not achievable through the far-field/surface-enhanced Raman, or the existing TERS techniques. Our TERS technique offers a powerful tool for accurately identifying Raman scattering of molecules, paving the way for biomolecular analysis.
High-speed and large-capacity visible light communication for 6G: advances and perspectives
Nan Chi, Zhilan Lu, Fujie Li, Haoyu Zhang, Yunkai Wang, Xinyi Liu, Zhiwu Chen, Zhe Feng, Zhuoran Hu, Zhixue He, Ziwei Li, Chao Shen, Junwen Zhang
Opto-Electronic Technology
2026-03-20
Holotomography-driven learning unlocks in-silico staining of single cells in flow cytometry by avoiding fluorescence co-registration
Daniele Pirone, Giusy Giugliano, Michela Schiavo, Annalaura Montella, Martina Mugnano, Vincenza Cerbone, Maddalena Raia, Giulia Scalia Ivana Kurelac, Diego Luis Medina, Lisa Miccio Mario Capasso, Achille Iolascon, Pasquale Memmolo, Pietro Ferraro
Opto-Electronic Science
2026-02-25
A hybrid integrated high-precision tunable semiconductor laser
Yiran Zhu, Botao Fu, Zhiwei Fang, Qiyue Hu, Jianping Yu, Yunpeng Song, Yu Ma, Min Wang, Kunpeng Jia, Zhenda Xie, Ya Cheng
Opto-Electronic Advances
2026-02-12
Millisecond-level electrically switchable metalens for adaptive rotational depth mapping and diffraction-limited imaging
Yeseul Kim, Jihae Lee, Won-Sik Kim, Hyeonsu Heo, Dongmin Jeon, Beomha Yang, Xiaotong Li, Harit Keawmuang, Shiqi Hu, Young-Ki Kim, Trevon Badloe, Junsuk Rho
Opto-Electronic Advances
2026-02-12
