(Peer-Reviewed) Terahertz technology in intraoperative neurodiagnostics: A review
Nikita V. Chernomyrdin ¹ ², Guzel R. Musina ¹, Pavel V. Nikitin ³, Irina N. Dolganova ² ⁴, Anna S. Kucheryavenko ¹ ⁴, Anna I. Alekseeva ³ ⁵, Yuye Wang 王与烨 ⁶, Degang Xu 徐德刚 ⁶, Qiwu Shi 施奇武 ⁷, Valery V. Tuchin ⁸ ⁹, Kirill I. Zaytsev ¹ ²
¹ Prokhorov General Physics Institute of the Russian Academy of Sciences, Moscow 119991, Russia
² Bauman Moscow State Technical University, Moscow 105005, Russia
³ Institute for Regenerative Medicine, Sechenov University, Moscow 119991, Russia
⁴ nstitute of Solid State Physics of the Russian Academy of Sciences, Chernogolovka 142432, Russia
⁵ Research Institute of Human Morphology, Moscow 117418, Russia
⁶ School of Precision Instrument and Optoelectronic Engineering, Tianjin University, Tianjin 300000, China
中国 天津 天津大学精密仪器与光电子工程学院
⁷ College of Materials Science and Engineering, Sichuan University, Chengdu 610000, China
中国 成都 四川大学材料科学与工程学院
⁸ Science Medical Center, Saratov State University, Saratov 410012, Russia
⁹ Institute of Precision Mechanics and Control, FRC "Saratov Scientific Centre of the Russian Academy of Sciences", Saratov 410028, Russia
Terahertz (THz) technology offers novel opportunities in biology and medicine, thanks to the unique features of THz-wave interactions with tissues and cells. Among them, we particularly notice strong sensitivity of THz waves to the tissue water, as a medium for biochemical reactions and a main endogenous marker for THz spectroscopy and imaging.
Tissues of the brain have an exceptionally high content of water. This factor, along with the features of the structural organization and biochemistry of neuronal and glial tissues, makes the brain an exciting subject to study in the THz range.
In this paper, progress and prospects of THz technology in neurodiagnostics are overviewed, including diagnosis of neurodegenerative disease, myelin deficit, tumors of the central nervous system (with an emphasis on brain gliomas), and traumatic brain injuries. Fundamental and applied challenges in study of the THz-wave – brain tissue interactions and development of the THz biomedical tools and systems for neurodiagnostics are discussed.