Year
Month
(Peer-Reviewed) Deep learning enhanced NIR-II volumetric imaging of whole mice vasculature
Sitong Wu 吴丝桐 ¹ ², Zhichao Yang 杨志超 ¹ ², Chenguang Ma 马晨光 ¹, Xun Zhang 张勋 ¹, Chao Mi 米超 ¹, Jiajia Zhou 周佳佳 ², Zhiyong Guo 郭智勇 ¹ ³, Dayong Jin 金大勇 ¹ ² ³
¹ UTS-SUSTech Joint Research Centre for Biomedical Materials & Devices, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen 518055, China
中国 深圳 南方科技大学生物医学工程系 南方科技大学-悉尼科技大学生物医学材料与仪器联合研究中心
² Institute for Biomedical Materials & Devices, Faculty of Science, University of Technology Sydney, Ultimo, New South Wales 2007, Australia
³ Guangdong Provincial Key Laboratory of Advanced Biomaterials, Southern University of Science and Technology, Shenzhen 518055, China
中国 深圳 南方科技大学 广东省先进生物材料重点实验室
Opto-Electronic Advances, 2023-04-28
Abstract

Fluorescence imaging through the second near-infrared window (NIR-II,1000–1700 nm) allows in-depth imaging. However, current imaging systems use wide-field illumination and can only provide low-contrast 2D information, without depth resolution.

Here, we systematically apply a light-sheet illumination, a time-gated detection, and a deep-learning algorithm to yield high-contrast high-resolution volumetric images. To achieve a large FoV (field of view) and minimize the scattering effect, we generate a light sheet as thin as 100.5 μm with a Rayleigh length of 8 mm to yield an axial resolution of 220 µm. To further suppress the background, we time-gate to only detect long lifetime luminescence achieving a high contrast of up to 0.45Ιcontrast. To enhance the resolution, we develop an algorithm based on profile protrusions detection and a deep neural network and distinguish vasculature from a low-contrast area of 0.07Ιcontrast to resolve the 100 μm small vessels.

The system can rapidly scan a volume of view of 75 × 55 × 20 mm3 and collect 750 images within 6 mins. By adding a scattering-based modality to acquire the 3D surface profile of the mice skin, we reveal the whole volumetric vasculature network with clear depth resolution within more than 1 mm from the skin. High-contrast large-scale 3D animal imaging helps us expand a new dimension in NIR-II imaging.
Deep learning enhanced NIR-II volumetric imaging of whole mice vasculature_1
Deep learning enhanced NIR-II volumetric imaging of whole mice vasculature_2
Deep learning enhanced NIR-II volumetric imaging of whole mice vasculature_3
Deep learning enhanced NIR-II volumetric imaging of whole mice vasculature_4
  • Multi-wavelength nanowire micro-LEDs for future high speed optical communication
  • Ayush Pandey, Zetian Mi
  • Opto-Electronic Advances
  • 2024-03-20
  • Luminescence regulation of Sb3+ in 0D hybrid metal halides by hydrogen bond network for optical anti-counterfeiting
  • Dehai Liang, Saif M. H. Qaid, Xin Yang, Shuangyi Zhao, Binbin Luo, Wensi Cai, Qingkai Qian, Zhigang Zang
  • Opto-Electronic Advances
  • 2024-03-20
  • Breaking the optical efficiency limit of virtual reality with a nonreciprocal polarization rotator
  • Yuqiang Ding, Zhenyi Luo, Garimagai Borjigin, Shin-Tson Wu
  • Opto-Electronic Advances
  • 2024-03-20
  • Ultrahigh performance passive radiative cooling by hybrid polar dielectric metasurface thermal emitters
  • Yinan Zhang, Yinggang Chen, Tong Wang, Qian Zhu, Min Gu
  • Opto-Electronic Advances
  • 2024-03-12
  • Simultaneously realizing thermal and electromagnetic cloaking by multi-physical null medium
  • Yichao Liu, Xiaomin Ma, Kun Chao, Fei Sun, Zihao Chen, Jinyuan Shan, Hanchuan Chen, Gang Zhao, Shaojie Chen
  • Opto-Electronic Science
  • 2024-02-29
  • Generation of lossy mode resonances (LMR) using perovskite nanofilms
  • Dayron Armas, Ignacio R. Matias, M. Carmen Lopez-Gonzalez, Carlos Ruiz Zamarreño, Pablo Zubiate, Ignacio del Villar, Beatriz Romero
  • Opto-Electronic Advances
  • 2024-02-26
  • Acousto-optic scanning multi-photon lithography with high printing rate
  • Minghui Hong
  • Opto-Electronic Advances
  • 2024-02-26
  • Tailoring electron vortex beams with customizable intensity patterns by electron diffraction holography
  • Pengcheng Huo, Ruixuan Yu, Mingze Liu, Hui Zhang, Yan-qing Lu, Ting Xu
  • Opto-Electronic Advances
  • 2024-02-26
  • Miniature tunable Airy beam optical meta-device
  • Jing Cheng Zhang, Mu Ku Chen, Yubin Fan, Qinmiao Chen, Shufan Chen, Jin Yao, Xiaoyuan Liu, Shumin Xiao, Din Ping Tsai
  • Opto-Electronic Advances
  • 2024-02-26
  • Data-driven polarimetric imaging: a review
  • Kui Yang, Fei Liu, Shiyang Liang, Meng Xiang, Pingli Han, Jinpeng Liu, Xue Dong, Yi Wei, Bingjian Wang, Koichi Shimizu, Xiaopeng Shao
  • Opto-Electronic Science
  • 2024-02-24
  • Towards the performance limit of catenary meta-optics via field-driven optimization
  • Siran Chen, Yingli Ha, Fei Zhang, Mingbo Pu, Hanlin Bao, Mingfeng Xu, Yinghui Guo, Yue Shen, Xiaoliang Ma, Xiong Li, Xiangang Luo
  • Opto-Electronic Advances
  • 2024-01-31
  • Broadband high-efficiency dielectric metalenses based on quasi-continuous nanostrips
  • Xiaohu Zhang, Qinmiao Chen, Dongliang Tang, Kaifeng Liu, Haimo Zhang, Lintong Shi, Mengyao He, Yongcai Guo, Shumin Xiao
  • Opto-Electronic Advances
  • 2024-01-31



  • Top-down control of bottom-up material synthesis @ nanoscale                                Beam splitter benefits from topological antichiral edge states
    About
    |
    Contact
    |
    Copyright © PubCard