Year
Month
(Peer-Reviewed) Deep learning enhanced NIR-II volumetric imaging of whole mice vasculature
Sitong Wu 吴丝桐 ¹ ², Zhichao Yang 杨志超 ¹ ², Chenguang Ma 马晨光 ¹, Xun Zhang 张勋 ¹, Chao Mi 米超 ¹, Jiajia Zhou 周佳佳 ², Zhiyong Guo 郭智勇 ¹ ³, Dayong Jin 金大勇 ¹ ² ³
¹ UTS-SUSTech Joint Research Centre for Biomedical Materials & Devices, Department of Biomedical Engineering, Southern University of Science and Technology, Shenzhen 518055, China
中国 深圳 南方科技大学生物医学工程系 南方科技大学-悉尼科技大学生物医学材料与仪器联合研究中心
² Institute for Biomedical Materials & Devices, Faculty of Science, University of Technology Sydney, Ultimo, New South Wales 2007, Australia
³ Guangdong Provincial Key Laboratory of Advanced Biomaterials, Southern University of Science and Technology, Shenzhen 518055, China
中国 深圳 南方科技大学 广东省先进生物材料重点实验室
Opto-Electronic Advances, 2023-04-28
Abstract

Fluorescence imaging through the second near-infrared window (NIR-II,1000–1700 nm) allows in-depth imaging. However, current imaging systems use wide-field illumination and can only provide low-contrast 2D information, without depth resolution.

Here, we systematically apply a light-sheet illumination, a time-gated detection, and a deep-learning algorithm to yield high-contrast high-resolution volumetric images. To achieve a large FoV (field of view) and minimize the scattering effect, we generate a light sheet as thin as 100.5 μm with a Rayleigh length of 8 mm to yield an axial resolution of 220 µm. To further suppress the background, we time-gate to only detect long lifetime luminescence achieving a high contrast of up to 0.45Ιcontrast. To enhance the resolution, we develop an algorithm based on profile protrusions detection and a deep neural network and distinguish vasculature from a low-contrast area of 0.07Ιcontrast to resolve the 100 μm small vessels.

The system can rapidly scan a volume of view of 75 × 55 × 20 mm3 and collect 750 images within 6 mins. By adding a scattering-based modality to acquire the 3D surface profile of the mice skin, we reveal the whole volumetric vasculature network with clear depth resolution within more than 1 mm from the skin. High-contrast large-scale 3D animal imaging helps us expand a new dimension in NIR-II imaging.
Deep learning enhanced NIR-II volumetric imaging of whole mice vasculature_1
Deep learning enhanced NIR-II volumetric imaging of whole mice vasculature_2
Deep learning enhanced NIR-II volumetric imaging of whole mice vasculature_3
Deep learning enhanced NIR-II volumetric imaging of whole mice vasculature_4
  • Deep-red and near-infrared organic lasers based on centrosymmetric molecules with excited-state intramolecular double proton transfer activity
  • Chang-Cun Yan, Zong-Lu Che, Wan-Ying Yang, Xue-Dong Wang, Liang-Sheng Liao
  • Opto-Electronic Advances
  • 2023-07-20
  • Encoding physics to learn reaction–diffusion processes
  • Chengping Rao, Pu Ren, Qi Wang, Oral Buyukozturk, Hao Sun, Yang Liu
  • Nature Machine Intelligence
  • 2023-07-17
  • Accurate medium-range global weather forecasting with 3D neural networks
  • Kaifeng Bi, Lingxi Xie, Hengheng Zhang, Xin Chen, Xiaotao Gu, Qi Tian
  • Nature
  • 2023-07-05
  • Highly sensitive and stable probe refractometer based on configurable plasmonic resonance with nano-modified fiber core
  • Jianying Jing, Kun Liu, Junfeng Jiang, Tianhua Xu, Shuang Wang, Tiegen Liu
  • Opto-Electronic Advances
  • 2023-06-25
  • In-flow holographic tomography boosts lipid droplet quantification
  • Michael John Fanous, Aydogan Ozcan
  • Opto-Electronic Advances
  • 2023-06-25
  • The second fusion of laser and aerospace—an inspiration for high energy lasers
  • Xiaojun Xu, Rui Wang, Zining Yang
  • Opto-Electronic Advances
  • 2023-06-25
  • Hot electron electrochemistry at silver activated by femtosecond laser pulses
  • Oskar Armbruster, Hannes Pöhl, Wolfgang Kautek
  • Opto-Electronic Advances
  • 2023-06-25
  • Highly sensitive microfiber ultrasound sensor for photoacoustic imaging
  • Perry Ping Shum, Gerd Keiser, Georges Humbert, Dora Juan Juan Hu, A. Ping Zhang, Lei Su
  • Opto-Electronic Advances
  • 2023-06-25
  • Integral imaging-based tabletop light field 3D display with large viewing angle
  • Yan Xing, Xing-Yu Lin, Lin-Bo Zhang, Yun-Peng Xia, Han-Le Zhang, Hong-Yu Cui, Shuang Li, Tong-Yu Wang, Hui Ren, Di Wang, Huan Deng, Qiong-Hua Wang
  • Opto-Electronic Advances
  • 2023-06-25
  • Microsphere femtosecond laser sub-50 nm structuring in far field via non-linear absorption
  • Zhenyuan Lin, Kuan Liu, Tun Cao, Minghui Hong
  • Opto-Electronic Advances
  • 2023-06-25



  • Top-down control of bottom-up material synthesis @ nanoscale                                Beam splitter benefits from topological antichiral edge states
    About
    |
    Contact
    |
    Copyright © PubCard