(Preprint) Metagenomic evidence for the coexistence of SARS and H1N1 in patients from 2007-2012 flu seasons
Qi Liu ¹ ² ⁴, Zhenglin Du 杜政霖 ² ³ ⁴, Sihui Zhu ² ³ ⁴, Wenming Zhao 赵文明 ² ³ ⁴, Hua Chen 陈华 ¹ ² ⁴, Yongbiao Xue 薛勇彪 ² ³ ⁴
¹ CAS Key Laboratory for Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China. 中国科学院 北京基因组研究所 精准基因组医学重点实验室
² China National Center for Bioinformation, Beijing 100101, China. 国家生物信息中心
³ National Genomics Data Center, Beijing Institute of Genomics, Chinese Academy of 10 Sciences, Beijing 100101, China. 北京基因组研究所 国家基因组科学数据中心
⁴ University of Chinese Academy of Sciences, Beijing 100049, China. 中国科学院大学
ChinaXiv
, 2021-08-11
Abstract
By re-analzying public metagenomic data from 101 patients infected with influenza A virus during the 2007-2012 H1N1 flu seasons in France, we identified 22 samples with SARS-CoV sequences. In 3 of them, the SARS genome sequences could be fully assembled out of each. These sequences are highly similar (99.99% and 99.7%) to the artificially constructed recombinant 5 SARS-CoV (SARSr-CoV) strains generated by the J. Craig Venter Institute in USA.
Moreover, samples from different flu seasons have different SARS-CoV strains, and the divergence between these strains cannot be explained by natural evolution. Our study also shows that retrospective studies using public metagenomic data from past major epidemic outbreaks serves as a genomic strategy for the research of origins or spread of infectious diseases.
Embedded solar adaptive optics telescope: achieving compact integration for high-efficiency solar observations
Naiting Gu, Hao Chen, Ao Tang, Xinlong Fan, Carlos Quintero Noda, Yawei Xiao, Libo Zhong, Xiaosong Wu, Zhenyu Zhang, Yanrong Yang, Zao Yi, Xiaohu Wu, Linhai Huang, Changhui Rao
Opto-Electronic Advances
2025-05-27
Wearable photonic smart wristband for cardiorespiratory function assessment and biometric identification
Wenbo Li, Yukun Long, Yingyin Yan, Kun Xiao, Zhuo Wang, Di Zheng, Arnaldo Leal-Junior, Santosh Kumar, Beatriz Ortega, Carlos Marques, Xiaoli Li, Rui Min
Opto-Electronic Advances
2025-05-27
Integrated photonic polarizers with 2D reduced graphene oxide
Junkai Hu, Jiayang Wu, Di Jin, Wenbo Liu, Yuning Zhang, Yunyi Yang, Linnan Jia, Yijun Wang, Duan Huang, Baohua Jia, David J. Moss
Opto-Electronic Science
2025-05-22
Structural color: an emerging nanophotonic strategy for multicolor and functionalized applications
Wenhao Wang, Long Wang, Qianqian Fu, Wang Zhang, Liuying Wang, Gu Liu, Youju Huang, Jie Huang, Haoyuan Zhang, Fuqiang Guo, Xiaohu Wu
Opto-Electronic Science
2025-04-25
