(Peer-Reviewed) Broadband ultrasound generator over fiber-optic tip for in vivo emotional stress modulation
Jiapu Li 李家普 ², Xinghua Liu 刘幸华 ¹ ³, Zhuohua Xiao 肖灼华 ², Shengjiang Yang 杨胜江 ², Zhanfei Li 李占飞 ¹ ³, Xin Gui 桂鑫 ⁴, Meng Shen 沈孟 ⁵, He Jiang 江河 ², Xuelei Fu 傅雪蕾 ², Yiming Wang 王一鸣 ², Song Gong 龚嵩 ¹ ³, Tuan Guo 郭团 ⁶, Zhengying Li 李政颖 ² ⁴
¹ Division of Trauma Surgery, Emergency Surgery & Surgical Critical, Tongji Trauma Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
中国 武汉 华中科技大学同济医学院附属同济医院 同济创伤中心创伤外科、急诊外科及外科重症医学科
² School of Information Engineering, Wuhan University of Technology, Wuhan 430070, China
中国 武汉 武汉理工大学信息工程学院
³ Department of Emergency and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
中国 武汉 华中科技大学同济医学院附属同济医院 急诊与重症医学科
⁴ National Engineering Research Center of Fiber Optic Sensing Technology and Networks, State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, China
中国 武汉 武汉理工大学 光纤传感技术与网络国家工程研究中心 材料复合新技术国家重点实验室
⁵ Hubei Key Laboratory of Micro-Nanoelectronic Materials and Devices, Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry of Education Key Laboratory of Green Preparation and Application for Functional Materials, and School of Microelectronics, Hubei University, Wuhan 430062, China
中国 武汉 湖北大学微电子学院 微纳电子材料与器件湖北省重点实验室 有机化工新材料湖北省协同创新中心 功能材料绿色制备与应用部教育重点实验室
⁶ Institute of Photonics Technology, Jinan University, Guangzhou 510632, China
中国 广州 暨南大学光子技术研究所
Opto-Electronic Science
, 2025-07-25
Abstract
Ultrasonic neuromodulation has gained recognition as a promising therapeutic approach. A miniature transducer capable of generating suitable-strength and broadband ultrasound is of great significance for achieving high spatial precision ultrasonic neural stimulation. However, the ultrasound transducer with the above integrated is yet to be challenged.
Here, we developed a fiber-optic photoacoustic emitter (FPE) with a diameter of 200 μm, featuring controllable sound intensity and a broadband response (−6 dB bandwidth: 162%). The device integrates MXene (Ti3C2Tx), known for its exceptional photothermal properties, and polydimethylsiloxane, which offers a high thermal expansion coefficient.
This FPE, exhibiting high spatial precision (lateral: 163.3 μm, axial: 207 μm), is capable of selectively activating neurons in targeted regions. Using the TetTagging method to selectively express a cfos-promoter-inducible mCHERRY gene within the medial prefrontal cortex (mPFC), we found that photoacoustic stimulation significantly and temporarily activated the neurons.
In vivo fiber photometry demonstrated that photoacoustic stimulation induced substantial calcium transients in mPFC neurons. Furthermore, we confirmed that photoacoustic stimulation of the mPFC using FPE markedly alleviates acute social defeat stress-induced emotional stress in mice. This work demonstrates the potential of FPEs for clinical applications, with a particular focus on modulating neural activity to regulate emotions.
Flicker minimization in power-saving displays enabled by measurement of difference in flexoelectric coefficients and displacement-current in positive dielectric anisotropy liquid crystals
Junho Jung, HaYoung Jung, GyuRi Choi, HanByeol Park, Sun-Mi Park, Ki-Sun Kwon, Heui-Seok Jin, Dong-Jin Lee, Hoon Jeong, JeongKi Park, Byeong Koo Kim, Seung Hee Lee, MinSu Kim
Opto-Electronic Advances
2025-09-25
Dual-frequency angular-multiplexed fringe projection profilometry with deep learning: breaking hardware limits for ultra-high-speed 3D imaging
Wenwu Chen, Yifan Liu, Shijie Feng, Wei Yin, Jiaming Qian, Yixuan Li, Hang Zhang, Maciej Trusiak, Malgorzata Kujawinska, Qian Chen, Chao Zuo
Opto-Electronic Advances
2025-09-25
